Pre- and Formulation Services
Drug Characterization
- Solubility
- pKa
- Log P
- Stability
- Cosolvent
- Cyclodextrin
- Dispersed systems
- Micro / nanoemulsions
- Lipsomes
- Nanoparticles
Pre-clinical Pk/PD Evaluations
Bioanalysis
- Method development and validation to quantitate concentrations of drug or metabolite in biological matrix
- Identification of unknown metabolite using accurate mass
In Vitro Metabolism
- Drug metabolism characterization using tissue microsomes. S9 fraction, and recombinant enzymes
- Metabolite profiling & identification
In Vitro Biopharm Characterization
- Membrane permeability and transporter identification
- Bindings to plasma proteins, albumin or a- glycoprotein
In Vivo PK
- PK studies in rats and mice after IV, oral, IP and SC drug administration
- Dose linearity PK studies
- Bioavailability studies
- PK studies on tissue distribution
In Vitro/In Vivo PD Assays
- Cell proliferation assay
- Apoptosis assay
- DNA damage assay
- Migration/invsion assays
- Xenograft assay
- Biomaker assays on tumors from xenograft models
- Genetic mouse models of PD assays
PK/PD Modeling and Simulation
- Consultation on experimental design
- PK modeling development and simulation
- PD modeling and determination of parameters
- PK/PD modeling
